Centrosome Amplification in Cancer Prognosis (IMAGE)
Caption
Centrosome amplification is a hallmark of cancer cells and therefore a promising target for cancer therapy. To circumvent the technical difficulties of profiling centrosome amplification in patient samples, we used the expression of 20 genes known to promote centrosome amplification (CA20) to estimate its relative prevalence across nearly 10,000 human tumours of over 30 cancer types. We found that those genes are indeed highly active in tumours and associated with cancer genome alterations and poor prognosis in different cancer types. By integrating these data with drug screenings in human cancer cell lines, we identify candidate drugs for selectively targeting cancer cells through centrosome amplification.
Credit
Bernardo de Almeida, iMM.
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