Number of Structures Available in the PDB Per Year through May 14, 2014 (IMAGE)

Rutgers University

Number of Structures Available in the PDB Per Year through May 14, 2014

Caption

Number of structures available in the PDB per year through May 14, 2014, with selected examples. Early structures included myoglobin (1; PDB ID 1mbn), the first structure solved by X-ray crystallography, and small enzymes (2; top: 4pti, bottom right: 2cha, bottom left: 3cpa). As technologies developed, the archive grew to host examples of tRNA (3; 6tna), viruses (4; 4rhv), antibodies (5; 1igt), protein-DNA complexes (6; top to bottom, 1j59, 1tro, 2bop, 1aoi), ribosomes (7; 1fjg, 1fka, 1ffk), and chaperones (8; 1aon).

Figure References: Myoglobin (PDB ID 1mbn): J. C. Kendrew, G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, D. C. Phillips. (1958) A three-dimensional model of the myoglobin molecule obtained by x-ray analysis. Nature 181: 662-666; J. C. Kendrew, R. E. Dickerson, B. E. Strandberg, R. G. Hart, D. R. Davies, D. C. Phillips, V. C. Shore. (1960) Structure of myoglobin: A three-dimensional Fourier synthesis at 2 A. resolution. Nature 185: 422-427; Enzymes (top, 4pti): M. Marquart, Walter, J., Deisenhofer, J., Bode, W., Huber, R. (1983) The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors. Acta Crystallogr B39: 480; (bottom left: 3cpa): D. W. Christianson, W. N. Lipscomb. (1986) X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature. Proc Natl Acad Sci U S A 83: 7568-7572; (bottom right: 2cha):J. J. Birktoft, D. M. Blow. (1972) Structure of crystalline alpha-chymotrypsin. V. The atomic structure of tosyl-alpha-chymotrypsin at 2 Å resolution. J Mol Biol 68: 187-240; tRNA (6tna): J. L. Sussman, S. R. Holbrook, R. W. Warrant, G. M. Church, S.-H. Kim. (1978) Crystal structure of yeast phenylalanine transfer RNA. I. Crystallographic refinement. J. Mol. Biol. 123: 607-630; Virus (4rhv): E. Arnold, M. G. Rossmann. (1988) The use of molecular-replacement phases for the refinement of the human rhinovirus 14 structure. Acta Crystallogr A 44 (Pt 3): 270-282; Antibody (1igt): L. J. Harris, S. B. Larson, K. W. Hasel, A. McPherson. (1997) Refined structure of an intact IgG2a monoclonal antibody. Biochemistry 36: 1581-1597; Protein-DNA

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