Development of Mature Sperm (1 of 2) (IMAGE) Kyoto University Caption Dephosphorylation of Protamine 2 at serine 56 is key in proper DNA packaging in developing sperm cells. However, dysfunction in Hspa4l results in Ppp1cc2 not dephosporylating Protamine 2. Credit Kyoto University/Itoh Lab Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.