Shedding Light on Sertoli Cell Function (IMAGE)

Cincinnati Children's Hospital Medical Center

Shedding Light on Sertoli Cell Function

Caption

Sertoli cells are highly polarized cells that nurture different stages of germ cells at the same time. This image reveals how a single Sertoli cell, which is genetically labeled with yellow fluorescent protein among other Sertoli cells in red, contacts a number of cells in the tubule. Scientists at Cincinnati Children’s have uncovered a critical role for the Rho GTPase CDC42 in regulating the polarity of Sertoli cells and maintaining steady-state sperm production.

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Cincinnati Children's

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