<i> De novo </i> protein (IMAGE) National Institutes of Natural Sciences Caption Structure of the <i>de</i> <i>novo</i> protein with most of the core filled with valine residues (green). Ten hydrophobic residues were mutated to smaller valine residues. This <i>de</i> <i>novo</i> protein still shows high thermal stability above 100 ºC. Credit NINS/IMS Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.