<i> De novo </i> protein (IMAGE) National Institutes of Natural Sciences Caption Structure of the de novo protein with most of the core filled with valine residues (green). Ten hydrophobic residues were mutated to smaller valine residues. This de novo protein still shows high thermal stability above 100 ºC. Credit NINS/IMS Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.