A schematic of tetrodotoxin delivery to nerve sodium channels via bioinspired nanofibers. (IMAGE)
Caption
The bio-inspired nanofibers carry two peptides (shown as arrays of blue and violet dots) that are modified from peptides on tetrodotoxins’ natural binding site on voltage-gated sodium channels. These adapted peptides bind to tetrodotoxin (shown as gold hexagons) and release it when the nanofibers are injected near the nerve, providing prolonged local anesthesia.
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Fantastic Color/Nature Biomedical Engineering
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