Three-dimensional structure of the yeast Mec1-Ddc2 complex (IMAGE)

University of Science and Technology of China

Three-dimensional structure of the yeast Mec1-Ddc2 complex

Caption

Three-dimensional structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. The genomes of eukaryotic cells are under continuous assault by external and internal factors. All cells have elaborate mechanisms to maintain their genomes and the ATR kinase is a master regulator of genomic stability. The two Mec1-Ddc2 monomers directly contact head-to-head through the upper catalytic core, which can immediately culminate in full kinase activity upon DNA damage.

Credit

©University of Science & Technology of China,Illustration: Guoyan Wang and Yanbing Ma;structure based on the cryo-EM map of a yeast Mec1-Ddc2 complex (EMDB ID EMD-6708)

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