Insulin-Secreting Beta Cells 2 (IMAGE)

Penn State

Insulin-Secreting Beta Cells 2

Caption

The insulin-secreting beta cells (green) normally exhibit a perinuclear cap of proinsulin (orange in left panel) whereas proinsulin is spread throughout the cytoplasm (orange in right panel) in many beta-cells of PERK-deficient mice, which are diabetic because of insufficient secretion of insulin.

Credit

Wei Zhang, Penn State

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