Translating Mitochondrial Signals to Nuclear DNA Changes and Cancer (IMAGE)

University of Pennsylvania

Translating Mitochondrial Signals to Nuclear DNA Changes and Cancer

Caption

A proposed model of hnRNPA2 (in gray) shows where acetyl-CoA (green) can "dock" and interact with different components of the protein. These interactions allow it to transfer acetyl-CoA groups to nuclear gene promoters and translate mitochondrial stress to nuclear gene activation, a process associated with cancer progression

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University of Pennsylvania

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