Graphical Summary (IMAGE) Osaka University Caption Expression of SEMA7A in human lung adenocarcinoma is regulated by the EGFR-mTOR axis and is involved in development of resistance to EGFR-TKIs. Resistance is mediated by inhibition of apoptosis by the SEMA7A-ITGB1–ERK axis. Credit ©2018, American Society for Clinical Investigation, <em>JCI Insight</em>. 2018;3(24):e123093. DOI: 10.1172/jci.insight.123093 Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.