Mdm2 Suppresses Cell Transformation (IMAGE)

Rockefeller University Press

Mdm2 Suppresses Cell Transformation

Caption

Mouse cells fail to thrive in suspension cultures when wild-type Mdm2 is expressed (left), but expression of a mutant form of Mdm2 (right), in combination with PGAM and an oncogenic protein called Ras, enhances glycolysis and promotes cell transformation (right).

Credit

Mikawa et al., 2014

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