Inhibition of Autolysis and Cell Separation in Bacterial Cultures (IMAGE)

Wiley

Inhibition of Autolysis and Cell Separation in Bacterial Cultures

Caption

Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 1000-10000-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations.

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(C) Wiley-VCH 2009

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Permission to use with appropriate credit and link to http://dx.doi.org/10.1002/anie.200803664

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