Nicotinamide Alleviates MS-Like Disease in Mice (IMAGE)

Boston Children's Hospital

Nicotinamide Alleviates MS-Like Disease in Mice

Caption

In mice with MS-like disease, nicotinamide delayed and reduced neurologic disability as indicated by behavioral scores (1 indicating mild weakness only in the tail; 4, paralysis involving all four limbs). Mice receiving placebo (saline) had the most disability, while mice receiving high-dose nicotinamide had the least. Wlds mice (which more readily convert nicotinamide to NAD) benefited most from treatment.

Credit

Courtesy Shinjiro Kaneko, MD, Neurobiology Program, Children's Hospital Boston

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