SAPH-ire Diagram (IMAGE)

Georgia Institute of Technology

SAPH-ire Diagram

Caption

SAPH-ire analyzes existing data repositories of protein modifications and 3-D protein structures to help scientists identify and target research on "hotspots" likely to be important for biological function. Shown is the structural projection of PTM hotspots onto the 3-D structure of a heterotrimeric G protein. Regions of the protein that are modified are color coded to indicate observation frequency. SAPH-ire integrates these and other features to predict which modifications are most likely to impact the function of the protein.

Credit

Credit: Torres Laboratory

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