Diagram (IMAGE) Hiroshima University Caption (A) Sequencing results and familial segregation of previously unidentified homozygous RORC mutations in three unrelated consanguineous families, indicating an autosomal recessive pattern of inheritance. All seven patients were born of consanguineous parents. (B) Graphical representation of the RORγ and RORγT proteins, encoded by RORC. Arrows indicate the location of the sites affected by the RORC mutations found in the families investigated in this study. DBD: DNA binding domain, LBD: ligand binding domain, AF2: activation function 2. Credit Hiroshima University Usage Restrictions This image may only be used with appropriate caption or credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.