Flip Versus Non-Flip DNA Repair Mechanism (IMAGE)

Vanderbilt University

Flip Versus Non-Flip DNA Repair Mechanism

Caption

The new type of DNA repair enzyme, AlkD on the left, can identify and remove a damaged DNA base without forcing it to physically "flip" to the outside of the DNA backbone, which is how all the other DNA repair enzymes in its family work, as illustrated by the human AAG enzyme on the right. The enzymes are shown in grey, the DNA backbone is orange, normal DNA base pairs are yellow, the damaged base is blue and its pair base is green.

Credit

Brandt Eichman, Vanderbilt University

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