Degenerating Interneurons in Frontotemporal Lobar Degeneration (FTLD) Mice (IMAGE)

Nagoya University

Degenerating Interneurons in Frontotemporal Lobar Degeneration (FTLD) Mice

Caption

(a) Poly-ubiquitin positive protein aggregates (arrows) in the hippocampus of aged FTLD mice (TDP-43 transgenic mice). (b) Immunofluorescence staining show these aggregates contain p62 and parvalbumin, a marker of interneurons (arrows). (c) Staining by parvalbumin antibody show intact (arrowheads) and degenerating interneurons (arrows) in the hippocampus of aged FTLD mice.

Credit

Hitomi Tsuiji and Koji Yamanaka

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