CtdE 1 (IMAGE) Rice University Caption Rice University chemical and biomolecular engineers led the discovery of a new biocatalyst, CtdE, used in this illustration to construct an alkaloid with a critical 3S-spirooxindole framework, as seen in blue in the bottom molecule. Their study also provides deeper insight into the mechanism of stereoselective catalysis. FAD (flavin adenine dinucleotide) and NADH (nicotinamide adenine dinucleotide) are cofactors used in the reaction. Credit Zhiwen Liu/Rice University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.