How Lamin-A Controls Cell Migration Via Nuclear Stiffness (IMAGE)

University of Pennsylvania

How Lamin-A Controls Cell Migration Via Nuclear Stiffness

Caption

To migrate to other parts of the body, a cell's nucleus must squeeze through pores -- and survive the trip. Too much lamin-A in the nucleus and it will be too stiff to fit through pores; too little and it will break apart in the process, killing the cell. Knowing the optimal level of lamin-A for keeping cells in place could have applications in cancer treatment and stem cell therapies.

Credit

University of Pennsylvania, <i>Journal of Cell Biology</i>

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