Validation of virus detection by the tumor profiling assay and novel virus associations (IMAGE)
Caption
A: Receiver operator characteristics (ROC) curve, the plot that depicts the trade-off between sensitivity and specificity, showing performance of virus detection compared to isothermal amplification method. The area under the ROC curve is 0.953. B: Forest plot showing enrichment of HHV6 in neuroblastoma, HHV7 in esophagogastric cancer, and HPV42 in non-melanoma skin cancer. Results are shown as an odds ratio comparing the enrichment for the virus in the specific tumor type compared to the other tumor types in the cohort. To the right of the figure, the odds ratio values and 95% confidence intervals are shown. C: The top panel shows a photomicrograph demonstrating the morphology of digital papillary adenocarcinoma by hematoxylin & eosin stain at 20X magnification, and the bottom panel shows photomicrograph of same tissue with RNA in situ hybridization custom designed to detect HPV42 demonstrating the localization of the virus to tumor cells. HHV-Human herpes virus; HPV-Human papillomavirus.
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The Journal of Molecular Diagnostics
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