Activating an Amygdala-Brainstem Pathway Relieves Pain and Improves Emotional State in Rats (IMAGE)
Caption
Selective activation of amygdala neurons projecting to the brainstem parabrachial nucleus alleviated pain and fear, and promoted positive affect in rats. The schematic diagram shows a working model in which pain drives negative emotion by affecting parabrachial neurons, while amygdala input to the parabrachial drives positive emotion. Activation of these amygdala neurons would be expected to relieve the emotional burden experienced by chronic pain patients, thus supporting their recovery and mental well-being.
Credit
Roni Hogri, 2022.
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