The Double Life of Alpha-Synuclein. (IMAGE) Brigham and Women's Hospital Caption A graphic depicts the “two faces of alpha-synuclein” and the transition from normal states (upper, organized molecular machines on a well-defined grid) to pathologic states in which there is membrane disruption, altered protein interactions and localization (lower, chaotic, disrupted machines, darker tone). Credit Artwork by Gergana Petrova. Usage Restrictions Reporters are free to use this image in news coverage of Hallacli E et al.’s paper in Cell with credit to Gergana Petrova. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.