Fewer chromosome segregation errors in modern human than Neanderthal neural stem cells. (IMAGE)

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)

Fewer chromosome segregation errors in modern human than Neanderthal neural stem cells.

Caption

Left side: microscopy image of the chromosomes (in cyan) of a modern human neural stem cell of the neocortex during cell division. Right side: same type of image, but of a cell where three amino acids in the two proteins KIF18a and KNL1, involved in chromosome separation, have been changed from the modern human to the Neanderthal variants. These “neanderthalized” cells show twice as many chromosome separation errors (red arrow).

Credit

Felipe Mora-Bermúdez / MPI-CBG

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