Illustration of an ExoN (IMAGE)
Caption
On the left, potential mechanism of action of nucleoside antivirals, exemplified by remdesivir, against SARS-CoV-2 replication and how the virus proofreading ExoN enzyme counteracts the antivirals by eliminating them from the virus RNA. On the right, the atomic structure of the SARS-CoV-2 ExoN enzyme captured in the moment that it recognizes and corrects a mismatch in the virus RNA. The region highlighted by a purple circle is of particular interest because it can serve as the binding site for small molecules that deactivates the ExoN enzyme.
Credit
Yang Yang
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