How protofibrils form from Aβ-oligomers. (IMAGE)

Forschungszentrum Juelich

How protofibrils form from Aβ-oligomers.

Caption

Small Aβ oligomers (left: cryo-electron microscopy) are clumps consisting of just a few Aβ molecules. They cluster together to form short, worm-like structures known as protofibrils (right: atomic force microscopy). In an acidic environment, the Aβ oligomers form very quickly and cluster to form large particles from which protofibrils are separated following neutralization of the pH value (right, red arrows).

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Forschungszentrum Jülich, HHU Düsseldorf / Wolfgang Hoyer

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