Genome refolding drives epigenetic adaptation (IMAGE) University of Pennsylvania School of Medicine Caption If you stretched the DNA fiber packed inside of a single cell, it would reach six feet long from end to end — that’s like fitting a ball of yarn twice the size of Manhattan into a tennis ball. To function properly, the strand must be folded just right. Penn researchers have discovered that genome refolding can reposition transcription factors and lead to cancer drug resistance. Credit R. Babak Faryabi, PhD, Penn Medicine Usage Restrictions Credit: R. Babak Faryabi, PhD, Penn Medicine License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.