Duke-NUS Kidney Regeneration (VIDEO) Duke-NUS Medical School This video is under embargo. Please login to access this video. To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Caption Researchers in Singapore and Germany have found that renal tubular cells, which line the tiny tubes inside kidneys, release interleukin-11 (IL-11), a scar-regulating protein, in response to kidney damage. This leads to increased expression of a gene that arrests cellular growth and promotes kidney dysfunction. In a preclinical model of human diabetic kidney disease, the scientists showed that turning off this process by administering an antibody that binds to IL-11 led to proliferation of the kidney tubule cells and reversal of fibrosis and inflammation, enabling damaged kidney cells to regenerate and restoring impaired kidney function. Credit Duke-NUS Medical School Usage Restrictions The video may only be reproduced together with the provided caption and credit. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.