Comparison of mice pancreatic islets with and without microexon splicing regulation (IMAGE)
Caption
The image shows pancreatic islets in mice, specialised tissues that host beta cells. On the left, a healthy pancreatic islet is shown with its typical morphology with alpha cells in the periphery and beta cells in the core of the islet. On the right, mice with a mutation in Srrm3 that knock out the cells’ ability to regulate microexon inclusion results in islets with altered morphology and cell identity. This and other functional alterations ultimately impacts on the release of insulin and the ability to control blood glucose levels.
Credit
Jonas Juan Mateu/Centre for Genomic Regulation
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License
CC BY-SA