Mature dendritic cell expressing Siglec-1 nanoclusters on the cell surface a few minutes after capture of HIV-like particles (IMAGE)

ICFO-The Institute of Photonic Sciences

Mature dendritic cell expressing Siglec-1 nanoclusters on the cell surface a few minutes after capture of HIV-like particles

Caption

Mature dendritic cell expressing Siglec-1 nanoclusters (green dots) on the cell surface a few minutes after capture of HIV-like particles (red dots). Right: Massive transformation of the dendritic cell morphology after 60 min of HIV engagement. Green corresponds to Siglec-1 nanoclusters, Cyan corresponds to HIV particles. Engagement of Siglec-1 nanoclusters with HIV particles leads to the formation of an actin-enriched ring structure that accumulates Siglec-1 and HIV particles together into a sack-like compartment.

Credit

ICFO

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