Binding mechanism of CELSR cadherin. (IMAGE) National Institutes of Natural Sciences Caption (A) Single-molecule fluorescence microscopy images of CELSR cadherins from adjacent cells. Two differently tagged CELSR cadherins (CELSR2-mGFP and CELSR2-Halo; indicated with arrows) colocalize between cells. (B) High-speed atomic force microscopy (HS-AFM) images of a complex of two interacting CELSR cadherins. A twisted conformation in the strand-like portions of the cadherin ectodomains is visualized using localization analysis of the HS-AFM images. Blue and orange colored arrowheads indicate the tip of each CELSR cadherin. Credit Shigetaka Nishiguchi of Scientists at the Exploratory Research Center on Life and Living Systems (ExCELLS) Usage Restrictions Credit must be given to the creator. No derivatives or adaptations of the work are permitted. License CC BY-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.