: Investigators analyzed a series of autopsies from patients with COVID-19 with late-stage lung disease at least 27 to 51 days after initial viral infection (IMAGE)

Elsevier

: Investigators analyzed a series of autopsies from patients with COVID-19 with late-stage lung disease at least 27 to 51 days after initial viral infection

Caption

The results reveal a bronchiolar-alveolar lung remodeling process that is characterized by i) basal epithelial cell hyperplasia and metaplasia with extension into former alveolar spaces; ii) colocalized depletion of alveolar types of epithelial cells normally found in these spaces; iii) epithelial stem progenitor cell differentiation to mucous cells with mucins characteristic of mucosal and submucosal locations; and iv) basal epithelial cell production of chemokine CXCL17 associated with lung monocyte-macrophage infiltration

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“Lung Remodeling Regions in Long-Term Coronavirus Disease 19 Feature Basal Epithelial Cell Reprogramming,” by Kangyun Wu, et al., The American Journal of Pathology

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