Switching the regioselectivity from ortho- to para-selectivity in the aza-Friedel−Crafts reaction (IMAGE)

Chiba University

Switching the regioselectivity from ortho- to para-selectivity in the aza-Friedel−Crafts reaction

Caption

An innovative bulky PyBidine-Ni(OAc)2 catalyst developed by Chiba University researchers expands the scope of aza-Friedel−Crafts reactions by favoring the production of para-substituted products over the conventional ortho-substituted products, opening new possibilities for generating a wide variety of novel compounds.

Credit

ACS Catalysis

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CC BY

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