Figure 1. Structure of the rotary sodium ion pump EhV-ATPase. (IMAGE)

National Institutes of Natural Sciences

Figure 1. Structure of the rotary sodium ion pump EhV-ATPase.

Caption

It consists of V1, which hydrolyzes ATP outside the cell membrane and rotates the central rotor subunits “D/F/d”, and Vo, which rotates the c-ring inside the cell membrane to transport sodium ions (Na+) from the inside to the outside of the cell. V1 is composed of seven protein subunits, “A, B, D, E, F, G, and d”, and Vo is composed of two protein subunits, “a and c”. V1 and Vo are connected by a subunit “E/G” called "stator" to fix the V1 and Vo domains. Previous studies have shown that the rotor tilts and connects with the c-ring (inset), but how the rotor rotates the c-ring remained a mystery.

Credit

Kazuyoshi Murata

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