Transforming process of liver progenitor cells (LPCs) into cancer stem cells (CSCs). (IMAGE)

First Hospital of Jilin University

Transforming process of liver progenitor cells (LPCs) into cancer stem cells (CSCs).

Caption

In a chronic inflammatory context, epigenetic changes occur in LPCs: (1) through a sustained stimulation by cytokines that either promotes dedifferentiation and transformation of LPCs to CSCs (IL-17, TNF-α and IL-6), or in contrast avoiding their transformation (IFN-γ, IL-27); (2) by hosting small non-coding RNAs transferred by exosomes coming from already established tumour cells or immune cells composing the microenvironment with a possible bidirectional communication. circRNA, circular RNA; IFN, interferon; IL, interleukin; LncRNA, long non-coding RNA; miRNA, microRNA; mRNA, messenger RNA; TNF, tumour necrosis factor; siRNA, small interference RNA.

Credit

by Arthur Brouillet and Fouad Lafdil

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License

CC BY-NC

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