TDP-43—a pathogenic protein—exhibits distinct neurological spreading patterns in amyotrophic lateral sclerosis (ALS) (IMAGE)

Niigata University

TDP-43—a pathogenic protein—exhibits distinct neurological spreading patterns in amyotrophic lateral sclerosis (ALS)

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Using novel mouse ALS models, researchers discovered that the pathogenic TDP-43 exhibits distinct propagation patterns in the corticospinal pathway and spinal circuits, providing insights into the mechanisms underlying the progressive neurodegeneration in ALS.

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Niigata University

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