Ambra1+ Myo-sEVsI/R enriched with mitochondrial components mediates ischemic cardiac fibrosis in a cGAS/STING dependent manner： a new communication medium between cardiomyocytes and fibroblasts (IMAGE)

Science China Press

Ambra1+ Myo-sEVsI/R enriched with mitochondrial components mediates ischemic cardiac fibrosis in a cGAS/STING dependent manner： a new communication medium between cardiomyocytes and fibroblasts

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Ambra1+-MYO-SEVS WERE INTERNALIZED BY FIBROBLASTS AND THE DELIVERED mtDNA COMPONENTS TO ACTIVATE THE FIBROBLAST cGAS-STING PATHWAY TO PROMOTE FIBROBLAST ACTIVATION AND PROLIFERATION.

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