Modification mechanism and substrate specificity of METTL8 (IMAGE)

Science China Press

Modification mechanism and substrate specificity of METTL8

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N-extension of METTL8-Iso1 is critical in m3C32 biogenesis while METTL8-Iso4 is inactive in m3C32 modification activity due to absence of the N-extension. METTL8-Iso1 exhibited a relaxed tRNA substrate specificity to modify several cytoplasmic or even bacterial tRNAs.

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