Embryonic Layering of the Brain (image)

Case Western Reserve University

Caption

Representative images of control (left) and Dvl mutants (right) embryonic brains at embryonic day 18.5 (E18.5, just before birth at E20) were stained with DAPI to highlight all of the nuclei (Blue), anti-Ctip2 (Green) for deep layer neurons and anti-Cux1 (Red) for more superficial layer neurons. Analysis of the results shows specific reduction of the deep layer (Ctip2+) neurons at E18.5. This reduction in deep layer neurons is preceded by a transient brain over growth at E14.5, associated with increased proliferation of neural progenitors and premature differentiation.

Credit

Case Western Reserve University School of Medicine

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