Littermates (siblings) were injected with either a control virus (right) or a virus that knocked out O-GlcNAcTransferase (OGT) (left) in a subpopulation of cells in the hypothalamus in the brain (αCaMKII-positive paraventricular neurons). OGT knock out made the mouse eat twice as much as its sibling. This photo was taken about five weeks after virus injection. This material relates to a paper that appeared in the March 18, 2016, issue of Science, published by AAAS. The paper, by O. Lagerlöf at Johns Hopkins University School of Medicine in Baltimore, Md., and colleagues was titled, "The nutrient sensor OGT in PVN neurons regulates feeding."
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