Cpf1 (image) Institute for Basic Science Share Print E-Mail Caption Cpf1 off-target effects were avoided by delivering Cpf1 and CRISPR-RNA complex, rather than plasmids encoding Cpf1 and crRNA. The accuracy of genome engineering was enhanced In this study, the researchers demonstrated methods to efficiently deliver CRISPR-Cpf1 genome engineering molecules. The researchers delivered pre-assembled protein-RNA complex (right) rather than using plasmid DNA that encodes Cpf1 and RNA (left), and showed DNA cleavage exclusively at target site. Credit Institute for Basic Science Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.