Therapeutic Target on Shape-Shifting Enzyme (image) National Institute of Standards and Technology (NIST) Share Print E-Mail Caption When efavirenz binds to CYP46A1 at the site shown in orange, it increases the flexibility of the protein in the region (magenta) around cholesterol (green). Regions with no changes are shown in grey and iron-containing heme in black. Credit Kyle Anderson/NIST Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.