Mitochondria Stress and Cancer (image) University of Pennsylvania Share Print E-Mail Caption Mitochondrial stress induces expression of nearly 120 genes involved in cell metabolism, morphology, resistance to apoptosis and cell invasion in addition upregulation of p53 by reduced expression of MDM2. Increased p53 levels negatively modulate Hif-1a levels by physical association and ubiquitination of the latter causing rapid degradation. In summary this work shows that mitochondrial stress induces altered cell metabolism in the absence of active Hif-1a pathway. Credit University of Pennsylvania Usage Restrictions In context of reporting Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.