This video highlights the rapid oscillation of an individual microbubble, initially about 3 micrometers in diameter. The oscillation, due to the exposure of this bubble to ultrasound, is occurring at one million times per second. The shear stress generated by the rapid expansions and contractions of this bubble is sufficient to poke holes in nearby cells, allowing for the entry of otherwise impermeable therapeutic compounds. The video recording, afforded by the UPMC-Cam, is captured at approximately 11 million frames per second. The total duration of this recording is 8 microseconds, and the scale bar is 5 micrometers.