Figure (image) National University of Singapore Share Print E-Mail Caption The shuttling of FHL2 between the focal adhesions and the nucleus in response to substrate stiffness. On soft surfaces, upon phosphorylation by FAK, FHL2 translocates to the nucleus, where it activates the synthesis of p21, cell proliferation inhibitor. On stiff surfaces, FHL2 is found at the focal adhesions. Credit Mechanobiology Institute, National University of Singapore Usage Restrictions Credit image accordingly to: Mechanobiology Institute, National University of Singapore Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.