Alzheimer's Disease Found to be a Diabetic Disorder of the Brain (image) Tohoku University Share Print E-Mail Caption Proposed model for blockade of Kir6.1 or Kir6.2 by memantine in hippocampus. Our results suggest that Kir6.2 blockade in dendritic spines by memantine regulates CaMKII activity by increasing intracellular Ca2+ mobilization, which in turn improves cognitive function by promoting AMPAR trafficking into the postsynaptic membrane. Credit Shigeki Moriguchi Usage Restrictions Credit: Shigeki Moriguchi Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.