Impact of Dietary Fiber on Gut Microbiome (image) University of Michigan Health System Share Print E-Mail Caption In experiments in germ-free mice that received a transplanted set of human gut microbes, a high-fiber diet was associated with a thick mucus layer in the colon's lining, and resistance to infection by a pathogen. But mice raised with a fiber-free diet had a much thinner, patchy mucus layer, as mucus-eating bacteria in the human microbe mix proliferated. The pathogen was able to get through to the cells of the colon wall. Credit University of Michigan Usage Restrictions Credit University of Michigan Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.