Sex Differences in Vision Loss In NF1 Explained (audio) Washington University School of Medicine Share Print E-Mail Loading audio... Caption Boys and girls with mutations in a gene called nf1 tend to develop tumors, and they have a significant risk of developing them on the optic nerve. But it turns out that girls are much more likely to have vision problems as a result of those tumors. Now, researchers at Washington University School of Medicine in St. Louis have found that the female hormone estrogen plays a role in that difference between boys and girls by revving up immune cells that damage the optic nerve, leading to vision loss. Jim dryden has the story. Credit Washington University BioMed Radio Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.