Down-Regulation of Pulmonary AQP-5 in AKI and its Recovery by AST-120 Treatment (image) Kumamoto University Share Print E-Mail Caption Indoxyl sulfate chemical formula (A left) and the epithelial sodium channel of lung alveolar cells (A-right). AQP-5 and Na+/K+-ATPase protein expressions of the lung in BNx rats. Protein expressions of AQP-5 and Na+/K+-ATPase of the lung in sham-operated rats (sham), BNx rats with (BNx + AST-120) or without (BNx) oral administration of AST-120 (2.5 g/kg) at 48hr, were determined by Western blot analysis (B, C) and Immunohistochemical analysis (D) with antibody against rAQP-5. Each column represents the mean +/- S.D. from 3 rats. **p < 0.01 versus sham; # p <0.05 versus BNx. Scale bars represent 20 micrometers. [Image and caption adapted from N. Yabuuchi, M. Sagata, C. Saigo, G. Yoneda, Y. Yamamoto, Y. Nomura, K. Nishi, R. Fujino, H. Jono, and H. Saito, 'Indoxyl sulfate as a mediator involved in dysregulation of pulmonary aquaporin-5 in acute lung injury caused by acute kidney injury,' International Journal of Molecular Sciences, vol. 18, p. 11, Dec. 2016. DOI: 10.3390/ijms18010011] Credit Dr. Hideyuki Saito Usage Restrictions This image may only be used in conjunction with the accompanying release, or stories written about the work described in the release with reference to the original work. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.