Garvan Institute researchers used cutting-edge intravital microscopy techniques to peer directly into pancreatic tumors inside a living animal, and to watch, in real time and in three dimensions, how priming with Fasudil altered the tumor and its surrounding stroma. They also watched how blood vessels surrounding the tumor were affected.
Dr. Marina Pajic says, "We saw the stroma weaken over time, and could also see that cancer cells did not spread so readily to secondary sites such as the liver.
"We also looked over time at the blood vessels supplying the tumor, using fluorescent quantum dots in the bloodstream. It was remarkable to watch the quantum dots radiate out from blood vessels adjacent to the tumors after Fasudil treatment -- which is an indicator that the vessels have become leaky."