YAP-Dependent Liver Size and Quality Controls (image) Tokyo Medical and Dental University Share Print E-Mail Caption Active YAP regulates the liver size through hepatocyte proliferation (left; known facts). In this study, we showed that active YAP selectively eliminates damaged hepatocytes (right). Hepatocytes expressing activated YAP in the presence of liver injury such as ethanol migrate into sinusoids, undergo apoptosis and are engulfed by Kupffer cells. Thus, a change in hepatocyte fate from proliferation to migration/apoptosis depends on a mechanism of stress detection involving YAP. Credit Department of Developmental and Regenerative Biology,TMDU Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.